Our brains need long-term care. Not quick fixes.
OUR BRAINS HAVE NEEDS
INGREDIENTS & BENEFITS
CLINICAL TRIAL
SCIENTIFIC ADVISORS
Our brains require an incredible amount of energy – all day, every day – to function.

Complex and delicate, our brains are extremely hungry organs. Everything they do – from storing new memories to firing off neurons – requires a constant supply of energy, even when we’re sleeping.

When they don’t get the energy and nutrients they need, our brains suffer.

Our brains get their energy from the food we eat. So, when it comes to brain health, what we eat matters. When our brains are deprived of energy and nutrients, they can’t take care of themselves – let alone take care of all the things on our to-do lists.

Burnout, stress, overwhelm, and fatigue are all signs of a hungry brain – and they’re bad for brain health.

Our brains weren’t designed to perform complex tasks all day – or take in, sort, and respond to a constant stream of new information. This depletes the brain of energy it needs to function, rest, and repair.

burnout

Stress

Anxiety

Fatigue

When we’re tired, stressed, or overwhelmed, the body can overproduce cortisol, the stress hormone. This negatively impacts our memory, sleep, cognition, and mood – and can promote inflammation. Chronic stress can also shrink the hippocampus, the part of the brain where memories are formed.

Our brains start to age in our 30s – and aging brains need support.

In our 30s and 40s, our brains begin to shrink. The process that generates energy in the brain slows down – meaning the brain needs to work harder to do its thing. Levels of grey and white matter decrease, and the brain’s performance – from processing speed to ability to recall – slowly declines.

As we age, our brains are also more susceptible to oxidative stress and chronic inflammation, both of which can accelerate aging. Oxidative stress is associated with a decline in memory and cognitive ability; and chronic inflammation can result in cellular degradation, a breakdown of metabolism, and altered brain chemistry.

Daily™ provides the brain with nutrients it needs to function and stay healthy for the long-term.*

Developed by neuroscientists, Daily™ supports foundational brain health by facilitating the production and sending of neurotransmitters; maintaining healthy neurons and cell membranes; and supporting the brain's ability to respond to oxidative stress.*

Cognitive health

Executive function, working memory, long-term memory, and focus.*

Mental Health

Our emotional, psychological, and social well-being.*

Neural Health

Brain health on the cellular level.*

Ingredients & Benefits

What’s in Daily™

The active ingredients in Daily™ are backed by extensive research and clinical studies and are represented in their clinically-studied doses. These ingredients fall into three categories: antioxidants, vitamins, and phosphatidylserine.

Antioxidants inhibit oxidation, a chemical reaction that can produce free radicals. The antioxidants in Daily™ are naturally occurring polyphenols – biologically active and beneficial plant compounds.*

Most essential vitamins and minerals can’t be synthesized by the body, which means we have to get them from the food we eat. The B vitamins in Daily™ are biologically available, meaning they’re already in the form that’s used in the body, saving us from extra effort.

Phosphatidylserine is a naturally-occurring phospholipid found in membranes throughout the body, with a particularly high concentration in the brain. Levels of phosphatidylserine can decline with age, which can impact brain cell communication, memory, sleep, and the stress response.*

Curcumin
from Longvida®
Function
  • Shields the brain from oxidative stress and inflammation*
Benefits
  • Supports working memory*
  • Helps reduce mental fatigue*
  • Supports mental resilience*
Memory*
Fatigue*
Calm*
Ginseng
from Cereboost®
Function
  • Supports healthy neurotransmitter levels*
  • Supports the brain's ability to respond to oxidative stress*
  • Increases Brain Derived Neurotrophic Factor (BDNF), a key molecule involved in plastic changes related to learning and memory*
Benefits
  • Supports cognitive function*
  • Eases brain fog*
  • Helps reduce mental fatigue*
Cognitive Health*
Brain Fog*
Burnout*
Green Tea Extract
EGCG, a polyphenol from green tea
Function
  • Supports healthy neurotransmitter levels*
Benefits
  • Helps maintain a healthy brain*
Cognitive Health*
Mental Health*
NEURAL Health*
Lemon Balm
from Cyracos®
Function
  • Helps to promote the production of calming neurotransmitters*
  • Increases GABA levels*
  • Has antioxidant properties*
Benefits
  • Supports calm while maintaining alertness*
Clarity*
Focus*
Calm*
Vitamin B6
as PFP
Function
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events
  • Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL Health*
NEURAL Health*
homocysteine levels*
Vitamin B9
as Quatrefolic®
Function
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events
    Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL Health*
NEURAL Health*
homocysteine levels*
Vitamin B12
72mg per serving
Function
  • Facilitates myelin synthesis, the insulating layer of protein and fatty substances that are involved in nerve signals*
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events*
  • Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL HEALTH*
NEURAL HEALTH*
homocysteine levels*
Phosphatidylserine
from SereinAid®
Function
  • Plays a key role in building and maintaining cell membranes*
  • Facilitates communication between brain cells*
Benefits
  • Supports working memory*
  • Supports a healthy stress response*
  • Supports attention and brain function*
  • Supports healthy sleep*
Stress*
Focus*
Sleep*
Memory*
Curcumin
from Longvida®
Function
  • Shields the brain from oxidative stress and inflammation*
Benefits
  • Supports working memory*
  • Helps reduce mental fatigue*
  • Supports mental resilience*
Memory*
Fatigue*
Calm*
Ginseng
from Cereboost®
Function
  • Supports healthy neurotransmitter levels*
  • Supports the brain's ability to respond to oxidative stress*
  • Increases Brain Derived Neurotrophic Factor (BDNF), a key molecule involved in plastic changes related to learning and memory*
Benefits
  • Supports cognitive function*
  • Eases brain fog*
  • Helps reduce mental fatigue*
Cognitive Health*
Brain Fog*
Burnout*
Green Tea Extract
EGCG, a polyphenol from green tea
Function
  • Supports healthy neurotransmitter levels*
Benefits
  • Helps maintain a healthy brain*
Cognitive Health*
Mental Health*
NEURAL Health*
Lemon Balm
from Cyracos®
Function
  • Helps to promote the production of calming neurotransmitters*
  • Increases GABA levels*
  • Has antioxidant properties*
Benefits
  • Supports calm while maintaining alertness*
Clarity*
Focus*
Calm*
Vitamin B6
as PFP
Function
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events
  • Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL Health*
NEURAL Health*
homocysteine levels*
Vitamin B9
as Quatrefolic®
Function
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events
    Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL Health*
NEURAL Health*
homocysteine levels*
Vitamin B12
72mg per serving
Function
  • Facilitates myelin synthesis, the insulating layer of protein and fatty substances that are involved in nerve signals*
  • Maintains healthy homocysteine levels*
  • Is a co-factor in hundreds of metabolic cellular events*
  • Is involved in DNA and RNA production*
  • Is involved in red cell formation*
  • Is involved in the metabolism of proteins, lipids, DNA, and other molecules throughout the body*
  • Is involved in the production of neurotransmitters*
  • Is involved in the synthesis of neurotransmitters*
Benefits
  • Supports cognitive health*
  • Supports mental health*
  • Supports neural health*
  • Maintains healthy homocysteine levels*
Cognitive Health*
MENTAL HEALTH*
NEURAL HEALTH*
homocysteine levels*
Phosphatidylserine
from SereinAid®
Function
  • Plays a key role in building and maintaining cell membranes*
  • Facilitates communication between brain cells*
Benefits
  • Supports working memory*
  • Supports a healthy stress response*
  • Supports attention and brain function*
  • Supports healthy sleep*
Stress*
Focus*
Sleep*
Memory*
View Full Supplement Facts
Nutrition Facts

Our Clinical Trial

We invested in an independent Phase 1 clinical trial to measure the impact of Daily™ on cognitive and mental health.

We partnered with Citruslabs, an independent, third-party contract research organization to run a 31-day clinical trial.


Results showed statistically significant improvements to brain function and well-being.* These results further substantiate the extensive research and testing behind each of the ingredients in Daily™ and confirm the validity and efficacy of Daily™’s formula.


Participants reported a reduction in occasional anxiety, brain fog, and burnout symptoms; improved focus and working memory; increases in productivity, energy levels, mental clarity; and the ability to handle daily stress.*

Phase I Clinical Trial

Advisors

Daily™ was formulated by a team of neuroscientists who literally wrote the book – or at least the scientific studies – on nutrients’ effects on the brain. Translating the hard science into a simple supplement that works and tastes good was no easy feat – that’s why our dream team also includes specialists in food science and the culinary arts. In addition to our formulators, our advisory board includes researchers, doctors, and nutrition experts.

Con Stough
PhD, Neuroscience

Advisor, Researcher, Formulator

Amy Bader
ND, Naturopathic Medicine

Medical Advisor

Robin Puskas
MFA, Culinary Arts

Culinary Formulator

David Kennedy
PhD, Neuroscience

Scientific Advisor & Researcher

Read more Less

Ingredient  Studies

An, Y., Feng, L., Zhang, X., Wang, Y., Wang, Y., Tao, L., Qin, Z. & Xiao, R. (2019). Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1. Clinical epigenetics 11, 1-19. https://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-019-0741-y.pdf

Bell, L., Whyte, A., Duysburgh, C., Marzorati, M., Van den Abbeele, P., Le Cozannet, R., Fança-Berthon, P., Fromentin, E. & Williams, C. (2022). A randomized, placebo-controlled trial investigating the acute and chronic benefits of American Ginseng (Cereboost®) on mood and cognition in healthy young adults, including in vitro investigation of gut microbiota changes as a possible mechanism of action. European Journal of Nutrition 61, 413-428. https://link.springer.com/content/pdf/10.1007/s00394-021-02654-5.pdf

Bender, A., Hagan, K. E. & Kingston, N. (2017). The association of folate and depression: A meta-analysis.  Journal of psychiatric research 95, 9-18.

Brown, A. L., Lane, J., Coverly, J., Stocks, J., Jackson, S., Stephen, A., Bluck, L., Coward, A. & Hendrickx, H. (2008). Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. British journal of nutrition 101, 886-894. https://www.cambridge.org/core/services/aop-cambridge-core/content/view/17BC9F6F4DB50E29307BF396BEAFAC77/S0007114508047727a.pdf/effects-of-dietary-supplementation-with-the-green-tea-polyphenol-epigallocatechin-3-gallate-on-insulin-resistance-and-associated-metabolic-risk-factors-randomized-controlled-trial.pdf

Chen, X., Guan, X., Tang, Y., Deng, J. & Zhang, X. (2022). Effects of cocoa products intake on cardiometabolic biomarkers of type 2 diabetes patients: a systematic review and meta-analysis based on both long-term and short-term randomised controlled trials. International Journal of Food Sciences and Nutrition, 1-17. 

Cheng, N., Bell, L., Lamport, D. J. & Williams, C. M. (2022). Dietary flavonoids and human cognition: a meta‐analysis. Molecular Nutrition & Food Research, 2100976. https://link.springer.com/content/pdf/10.1007/s00394-021-02654-5.pdf

Cox, K. H., Pipingas, A. & Scholey, A. B. (2015). Investigation of the effects of solid lipid curcumin on cognition  and mood in a healthy  older population. Journal of psychopharmacology 29, 642-651.

Cox, K. H., White, D. J., Pipingas, A., Poorun, K. & Scholey, A. (2020). Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study. Nutrients 12, 1678. https://www.mdpi.com/2072-6643/12/6/1678/htm

de Vries, K., Medawar, E., Korosi, A. & Witte, A. V. (2021). The Effect of Polyphenols on Working and Episodic  Memory in Non-pathological and Pathological Aging: A Systematic Review and Meta-Analysis. Frontiers in Nutrition 8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826433/pdf/fnut-08-720756.pdf

Desideri, G., Kwik-Uribe, C., Grassi, D., Necozione, S., Ghiadoni, L., Mastroiacovo, D., Raffaele, A., Ferri, L., Bocale, R. & Lechiara, M. (2012). Benefits in cognitive function, blood pressure, and insulin resistance through cocoa flavanol consumption in elderly subjects with mild cognitive impairment: the Cocoa, Cognition, and Aging (CoCoA) study. Hypertension (Dallas, Tex.: 1979) 60, 794. https://www.ahajournals.org/doi/epdf/10.1161/HYPERTENSIONAHA.112.193060

EFSA (2010a). Scientific Opinion on the substantiation of health claims related to vitamin B6 and contribution to normal homocysteine metabolism (ID 73, 76, 199), maintenance of normal bone (ID 74), maintenance of normal teeth (ID 74), maintenance of normal hair (ID 74), maintenance of normal skin (ID 74), maintenance of normal nails (ID 74), contribution to normal energy-yielding metabolism (ID 75, 214), contribution to normal psychological functions (ID 77), reduction of tiredness and fatigue (ID 78), and contribution to normal cysteine synthesis (ID 4283) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 8, 1759. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2010.1759

EFSA (2010b). Scientific Opinion on the substantiation of health claims related to vitamin B12 and contribution  to normal neurological and psychological functions (ID 95, 97, 98, 100, 102, 109), contribution to normal homocysteine metabolism (ID 96, 103, 106), maintenance of normal bone (ID 104), maintenance of normal teeth (ID 104), maintenance of normal hair (ID 104), maintenance of normal skin (ID 104), maintenance of normal nails (ID 104), reduction of tiredness and fatigue (ID 108), and cell division (ID 212) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA Journal 8, 1756. https://efsa.onlinelibrary.wiley.com/doi/epdf/10.2903/j.efsa.2010.1756

Fusar-Poli, L., Gabbiadini, A., Ciancio, A., Vozza, L., Signorelli, M. S. & Aguglia, E. (2021). The effect of cocoa-rich products on depression, anxiety, and mood: A systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition, 1-13.

Kang, E. Y., Cui, F., Kim, H. K., Nawaz, H., Kang, S., Kim, H., Jang, J. & Go, G.-w. (2022). Effect of phosphatidylserine on cognitive function in the elderly: A systematic review and meta-analysis. Korean Journal of Food Science and Technology 54, 52-58.

Kennedy, D., Little, W. & Scholey, A. (2004a). Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosomatic medicine 66, 607.

Kennedy, D. O., Wake, G., Savelev, S., Tildesley, N. T., Perry, E. K., Wesnes, K. A. & Scholey, A. B. (2003b). Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacology 28, 1871-81. https://www.nature.com/articles/1300230.pdf

Li, S., Guo, Y., Men, J., Fu, H. & Xu, T. (2021). The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults:a systematic review and meta-analysis. BMC geriatrics 21, 1-14. https://bmcgeriatr.biomedcentral.com/track/pdf/10.1186/s12877-021-02253-3.pdf

Lin, X., Zhang, I., Li, A., Manson, J. E., Sesso, H. D., Wang, L. & Liu, S. (2016). Cocoa flavanol intake and biomarkers for cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. The Journal of nutrition 146, 2325-2333. https://academic.oup.com/jn/article/146/11/2325/4630468

Liu, X., Du, X., Han, G. & Gao, W. (2017). Association between tea consumption and risk of cognitive disorders: A dose-response meta-analysis of observational studies. Oncotarget 8, 43306. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522147/pdf/oncotarget-08-43306.pdf

Mastroiacovo, D., Kwik-Uribe, C., Grassi, D., Necozione, S., Raffaele, A., Pistacchio, L., Righetti, R., Bocale, R.,  Lechiara, M.C., Marini, C.,Ferri, C. & Desideri, G. (2015). Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study--a randomized controlled trial. Am J Clin Nutr 101, 538-48. https://academic.oup.com/ajcn/article/101/3/538/4569408

Ossoukhova, A., Owen, L., Savage, K., Meyer, M., Ibarra, A., Roller, M., Pipingas, A., Wesnes, K. & Scholey, A. (2015). Improved working memory performance following administration of a single dose of American ginseng (Panax quinquefolius L.) to healthy middle‐age adults. Human Psychopharmacology: Clinical and Experimental 30, 108-122.

Scholey, A., Gibbs, A., Neale, C., Perry, N., Ossoukhova, A., Bilog, V., Kras, M., Scholz, C., Sass, M. & Buchwald-Werner, S. (2014). Anti-stress effects of lemon balm-containing foods. Nutrients 6, 4805-4821. https://www.mdpi.com/2072-6643/6/11/4805/htm

Wu, Y., Zhang, L., Li, S. & Zhang, D. (2022). Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis. Nutrition Reviews 80, 351-366.